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KMID : 1134820000290030448
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 3 p.448 ~ p.452
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Effects of Phloroglucinol Isolated from Ecklonia stolonifera on the Acetaminophen - Metabolizing Enzyme System in Rat
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Park Jong-Cheol
Hur Jong-Moon
Park Ju-Gwon
Kim Hyun-Joo
Chun Soon-Sil
Choi Jae-Sue
Choi Jong-Won
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Abstract
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Phloroglucinol isolated from Ecklonia stolonifera prevented the acetaminophen (800 mg/kg, i.p.)- induced rats as evidenced by the decreased formation of lipid peroxide. The activities of cytochrome P-450, animopyrine N-demethylase and aniline hydroxylase were not changed by the treatment with phenolic compound as compared with acetaminophen-treated rats. The glutathione S-transferase activity was decreased by the treatment of acetaminophen. This enzyme activity was restored in liver of pretreated-rats given by phloroglucinol. Pretreatment of this compound marked the liver protective activities as recovering the decreased glutathione level and glutathione reductase activity in rats treated with acetaminophen. But γ-glutamylcystein synthetase activity was not changed. The results suggest that the acetaminophen- induced hepatic lipid peroxidation may be reduced by enhancing the activity of glutathione S-transferase.
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KEYWORD
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Ecklonia stolonifera, phloroglucinol, acetaminophen-treated rat, lipid peroxide, glutathione Stransferase, glutathione reductase
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